A Gayoso*, Z Steier*, R Lopez, J Regier, KL NAzor, A Streets†, N Yosef†. “Joint probabilistic modeling of paired transcriptome and proteome measurements in single cells” bioRxiv, DOI:

T Chen*, A Gupta*, M Zalavadia, A Streets†. “µCB-seq: Microfluidic cell barcoding and sequencing for high-resolution imaging and sequencing of single cells” bioRxiv, DOI: 10.1101/2020.02.18.954974 pdf


A Gayoso, R Lopez, Z Steier, J Regier, A Streets†, N Yosef†. “A Joint Model of RNA Expression and Surface Protein Abundance in Single Cells” bioRxiv, DOI: pdf

N Altemose, A Maslan, A Lai, JA White, A Streets†. “μDamID: a microfluidic approach for imaging and sequencing protein-DNA interactions in single cells” bioRxiv  DOI: pdf

SE Bezci, B Werbner, M Zhou, KG Malollari, G Dorlhiac, C Carraro, A Streets, GD O’Connell†. “Radial variation in biochemical composition of the bovine caudal intervertebral disc” JOR Spine 2(3) DOI:

M Segal,  A Ingargiola, E Lerner, S Yoon Chung, JA White, A Streets , S Weiss, X Michalet†. “High-throughput smFRET analysis of freely diffusing nucleic acid molecules and associated proteins” Methods, 169:21-45 DOI:

Lai A, Altemose N, White JA, Streets A†. “On-ratio PDMS bonding for multilayer microfluidic device fabrication” Journal of Micromechanics and Microengineering, 29(10), 107001 DOI: 10.1101/450544 pdf


Gupta A, Dorlhiac G, Streets A†. “Quantitative imaging of lipid droplets in single cells” Analyst (2018) DOI: 10.1039/C8AN01525B pdf


White JA, Streets A†. “Controller for microfluidic large-scale integration” HardwareX (online 2017)

Chen T, Cao, C, Zhang J, Streets A, Huang Y†, Li T†. “Stimulated Raman Scattering Micro-dissection Sequencing (SMD-Seq) for Morphology-specific Genomic Analysis of Oral Squamous Cell Carcinoma” bioRxiv (2017) DOI: 10.1101/121616 pdf

Wu AR†, Wang L†, Streets A†, Huang Y†. “Single-Cell Transcriptional Analysis” Annual Review of Analytical Chemistry, Vol 10 (2017) pdf


Cao C, Zhou D, Chen T, Streets A†, Huang Y†. “Label-free digital quantification of lipid droplets in single cells by stimulated Raman microscopy on a microfluidic platform.” Analytical Chemistry, 88(9), 4931-4939  (2016) pdf


Streets A, Huang Y. “How deep is enough in single-cell RNA-seq?” Nature Biotech, 32, 1005-1006 (2014) pdf

Shen J, Jiang D, Fu Y, Wu X, Guo H, Feng B, Pang Y, Streets A, Tang F, Huang Y. “H3K4me3 epigenomic landscape derived from ChIP-Seq of 1,000 mouse early embryonic cells.” Cell Research 25:143–147.

Streets A, Li A, Chen T, Huang Y. “Imaging without fluorescence: Non-linear optical microscopy for quantitative cellular imaging.”  Analytical Chemistry, 96(17), p8506-8513, (2014) pdf

Streets A*, Zhang X*, Cao C, Pang Y, Wu X, Xiong L, Yang L, Fu Y, Zhao L, Tang F, and Huang Y. “Microfluidic single-cell whole-transcriptome sequencing.” Proceedings of the National Academy of Sciences, 111(19) 7048-7053 (2014) pdf

Streets A, Huang Y. “Microfluidics for biological measurements with single-molecule resolution.” Current Opinion in Biotechnology, 25(1), 69-77 (2014) pdf


Chen T, Lu F, Streets A, Fei P, Quan J, Huang Y. “Optical imaging of non-fluorescent nanodiamonds in live cells using transient absorption microscopy.” Nanoscale, 5, 4701 (2013)

Streets A, Huang Y. “Chip in a Lab: Microfluidics for next generation life science research.” Biomicrofluidics, 7 011302, (2013) pdf

Streets A, Sourigues Y, Kopito RR, Melki R, Quake SR. “Simultaneous measurement of amyloid fibril formation by dynamic light scattering and fluorescence reveal complex aggregation kinetics.” PLOS ONE, 8(1), e54541 (2013) pdf


Kim SH*, Streets A*, Lin RR, Quake SR, Weiss S, Majumdar DS. “High-throughput single-molecule optofluidic analysis.” Nature Methods, 8:3, 242-245 (2011)  pdf

-Highlighted in Physics Today ”Microfluidic devices streamline fluorescence experiments.” April (2011), p16-19 DOI: 10.1063/1.3580484

-Highlighted in Nature methods “News and Views: A triple threat to single molecules.” 8 213-215 DOI: 10.1038/nmeth0311-213



Streets A, Quake SR. “Ostwald ripening of clusters during protein    crystallization.” Physical Review Letters, 104, 178102 (2010) pdf

*contributed equally

†corresponding author

this link will direct you to Aaron’s publication list in google scholar